A 51-year-old cigarette-smoker man was admitted because of progressive generalized weakness and early fatigability since 3 months earlier. He denoted that his symptoms developed after 2 days of fasting. He also complained of headache, lower extremities bone pain, and a recent episode of respiratory tract infection. The patient was not on any specific medications, and physical examination was unremarkable. Laboratory results are shown in the Table.Results of hepatitis B and C viruses serology, serum complements 3 and 4, total hemolytic complement, antinuclear antibody, antineutrophilic cytoplasmic antibody, and anti-double-stranded DNA were all negative or in normal range. Urinalysis revealed proteinuria (2+) with 5 to 10 erythrocytes and 5 to10 leukocytes per high-power field. Serum protein electrophoresis demonstrated hypoalbuminemia, hypogmmaglobulinemia, and a monoclonal peak in the beta 2 region (Figure 1). With immunotyping, a high level of immunoglobulin A (IgA) was demonstrated (IgG, 196 mg/dL; IgA, 5965 mg/dL [reference range, 60 mg/dL to 490 mg/dL]; IgM, 6 mg/dL; and IgE, 14.2 mg/ dL). Result of urine protein electrophoresis also revealed beta, 97.0%; alpha 2, 1.0%; and albumin, 2.0%. There was no evidence of lytic bone lesions in skull radiography. Chest radiography was negative for cardiomegaly, pulmonary infiltrates, effusions, or bony abnormalities in the ribs...